Why Test for Zonulin, DAO, and Histamine?
The gastrointestinal tract is your body’s interface with the outside world. Foods, nutrients, medications, alcohol, pesticides, toxins, viruses, bacteria, and fungus all come into intimate contact with your body through your gut. Up to 80% of the immune system is located in the gastrointestinal tract. Together, the gut and the immune system act like a watchdog for your health. They have to figure out (1) what are the safe things to let into the body and (2) what are the bad things that should be kept out, attacked, or destroyed.
When the gut barrier becomes damaged from food allergens, chemicals, antibiotics, junk food, or infection, this important watchdog function can be compromised. This is called intestinal permeability, or “leaky gut,” and it means that the watchdog is off duty. Leaky gut means the GI barrier is broken down, so even bad things can leak through and cause symptoms for a person.
￼Symptoms associated with high histamine or low diamine oxidase:
• “Sensitive to everything”
What Does the Test Tell Me?
Your doctor may use the Zonulin/DAO/Histamine Profile to analyze your body’s watchdog system to see if it’s working properly. It is a blood test that looks for leaky gut, allergic inflammation, and the body’s ability to decrease inflammation in the gut. Your zonulin level tells your doctor if you have leaky gut. Diamine oxidase (DAO) and histamine can tell your doctor if you have problems breaking down histamine or if there is inflammation causing allergic-type symptoms. If you have GI symptoms such as reflux, irritable bowel disease, chronic diarrhea, or food sensitivities, then your doctor is looking for the underlying cause of these symptoms by running the Zonulin/DAO/Histamine Profile.
￼￼Specific food triggers that cause:
• Low blood pressure
• Abnormal menstrual cycles
What Will My Doctor Recommend If My Results are Abnormal?
If your zonulin results are high, then your doctor will institute a program of gut-healing. There are many natural therapies that can get your watchdog system working properly again. If your diamine oxidase is low and/or you have high histamine, then your doctor may give you supplements to help your body break down histamine effectively. Your doctor might also recommend dietary changes and supplements for gut repair such as probiotics to help your gut-immune system heal. With a combination of diet, supplements, and nutrition, your gut will get healthier, your watchdog system will recover, and your body will do a better job determining what is healthy versus what is a threat. Many GI symptoms, food sensitivities, and autoimmune diseases can be improved with this strategy.
￼Symptoms associated with high zonulin:
• Gluten sensitivity
• Food allergies
• Autoimmune disorders
• Multiple sclerosis
• Rheumatoid arthritis
Want More Information on Testing Offered at Progressive Medical Center?
For more information on the Zonulin/DAO/Histamine testing offered at Progressive Medical Center, and to get to the root cause of your GI condition, please give us a call today, or contact us at our location nearest you!