Retatrutide + GLP-1s: A New Frontier in Weight Loss Care

One of the most exciting developments in obesity medicine today is Retatrutide, a next-generation “triple agonist” medication that’s showing record-breaking results in clinical trials.

When combined or sequenced with other GLP-1 therapies like semaglutide or tirzepatide, Retatrutide may deliver even greater outcomes — giving patients who have plateaued a new path forward.

What is Retatrutide?

Retatrutide (LY-3437943) is an investigational medication that acts on three different hormone pathways at once:

• GLP-1 receptor: reduces appetite, slows digestion, improves insulin release.

• GIP receptor: supports insulin sensitivity and enhances satiety.

• Glucagon receptor: mobilizes fat and increases energy expenditure.

This unique triple action means Retatrutide doesn’t just help you eat less — it may also help your body burn more calories and shed visceral fat more effectively.

How Does It Compare to Other GLP-1 Medications?

GLP-1 therapies like semaglutide (Ozempic®, Wegovy®) and tirzepatide (Mounjaro®, Zepbound®) have already set the standard for medical weight loss. But Retatrutide is raising the bar:

• Greater weight loss: Clinical trials show patients losing up to 24% of body weight over 48 weeks — significantly higher than many GLP-1s.

• Improved metabolism: Beyond weight loss, Retatrutide has been shown to reduce liver fat, lower cholesterol, and improve insulin resistance.

• More complete fat loss: Its glucagon receptor activity may help increase energy burn and target stubborn belly fat.

Using Retatrutide Alongside Other GLP-1s

Because Retatrutide is still in clinical development, many patients may already be on a GLP-1 program. Here’s where it may fit into a progressive weight loss journey:

• Switching: For patients plateauing on semaglutide or tirzepatide, Retatrutide may provide the next breakthrough.

• Sequencing: Starting with GLP-1 therapy to build tolerance, then transitioning to Retatrutide for deeper results.

• Combination approaches: In select cases, carefully supervised regimens may maximize both appetite suppression and energy expenditure.

At Progressive Medical Center, our medical team tailors every program to the patient — ensuring safe transitions, minimizing side effects, and supporting long-term sustainability.

Who Can Benefit Most?

Retatrutide may be especially promising for:

• Patients who have struggled to lose weight despite GLP-1 therapy

• Individuals with obesity complicated by diabetes, fatty liver, or cardiovascular risk factors

• Patients seeking a more comprehensive metabolic reset rather than just weight reduction

Safety & Current Status

It’s important to know:

• Retatrutide is not yet FDA-approved and is currently available only through clinical research and select specialty clinics.

• Common side effects include nausea, diarrhea, constipation, and other gastrointestinal symptoms — similar to GLP-1s.

• Careful medical oversight is required to determine eligibility, adjust dosing, and monitor for potential risks.

Why Choose Progressive Medical Center?

Weight loss isn’t just about numbers on the scale — it’s about restoring your health, energy, and confidence. At Progressive Medical Center, our program combines:

• Cutting-edge medical therapies like GLP-1s and Retatrutide

• Nutrition and lifestyle coaching

• Metabolic testing and close clinical monitoring

• Long-term support to keep results sustainable

We don’t just hand you a prescription — we build a partnership for lasting transformation.