In the final episode on autoimmune diseases, Dr. Agolli and Dr. Burdette discuss:
The gut is often referred to as the origin of many autoimmune diseases due to its role in regulating the immune system. The gut microbiome, which is the community of microorganisms living in the human gut, plays a crucial role in maintaining gut health and regulating the immune system. Dysbiosis, or an imbalance in the gut microbiome, has been linked to a variety of autoimmune diseases.
Zonulin is a protein that regulates the permeability of tight junctions between cells in the wall of the digestive tract. When zonulin levels are high, it can cause the tight junctions to open, leading to increased intestinal permeability or “leaky gut.” This can allow bacteria and other substances to pass through the intestinal wall and into the bloodstream, triggering an immune response.
Dysbiosis of potentially autoimmune microbes together with high fecal zonulin is a telltale pattern for an autoimmune process1. When zonulin is high, it’s a sign that the tight junctions in the gut epithelium are wide open1. If a patient has microbial dysbiosis with a high zonulin, it takes gut dysbiosis to a whole other level – a systemic level1.
These are reasons why treatment for the risk of many autoimmune diseases begins with treating gut dysfunction. To here how, and much more, press play on the podcast.