Business man at the office feeling bad representing oxidative stress

Stress: Measuring Oxidative Stress and How to Lower It

The paradox: We spend a lot of money and time on increasing our antioxidant intake through foods and supplements. Yet most of us never know if this effort is making any impact on our health.

Should we be checking our oxidative stress levels as often as we check our cholesterol?


Not a day goes past that we don’t hear about oxidative stress in the news and interwebs, and how it is shortening our lifespan or causing diseases like heart disease, diabetes, and cancer. You also know that antioxidants protect us from oxidative stress. And you most probably spend some of your dollars on antioxidants through healthy food choices and supplements.

But how do you know if those dollars spent reward you with any real benefit? Let’s look into measuring oxidative stress, how to use biomarkers to assess your health status, and whether your antioxidant purchasing efforts are paying off.

Oxidative Stress is Not Good

Oxidative stress is behind many illnesses and diseases in the body and brain. A few of the major ones are:


Cancer is like a seed. Not every seed sprouts. Not every seed produces a plant. Not every seed produces fruit. BUT provided the right environment, the seed can thrive…cancer can thrive. Oxidative stress is the fertile soil for cancer to grow. Oxidative stress is your best biomarker as a risk factor for cancer.

Heart disease

Oxidative stress is the main contributor to why cholesterol becomes “truly bad” plaque.


  • Depression. An environment high in oxidative stress makes it very difficult for the body to produce serotonin in the brain. As it is one of the main happy chemicals, high levels of free radicals/high levels of oxidative stress are major contributors to serotonin deficiency.
  • Autism. One of the reasons we see autism in our patients is that their detoxification system isn’t cleaning out the byproducts fast enough. That is, there are too many free radicals floating around and not enough “cleaners” to move them out of the body and brain.

Testing for Oxidative Stress

The simplest biomarker to test for oxidative stress is a first-morning urine test to see if someone has too much oxidative stress overall.

Oxidative stress can affect different areas of the body, and different parts of the cell. Another way to say this: there are different parts of the oxidative stress system. Fortunately, there are 30 biomarkers are currently available for testing oxidative stress.

Certain markers are more associated with certain conditions. For example, the Cytosol of the cell is associated with ALS. Damage to the Mitochondria is associated with Fatigue & Cancer.

Some key markers for oxidative stress:

  • Oxidized LDL (Advanced Cholesterol Testing) marker. This is the “truly bad” cholesterol that ends up forming plaques. It is not a typical test, but JAMA says this test is 17x more predictive of heart disease than standard cholesterol testing.
  • Fat cell damage. The brain is 85% fat. The membrane of every cell is fat. If your fats are damaged, you’re more likely to have fat in the body. Not good.
  • Histamine markers
  • Cytosol damage
  • Mitochondrial damage
  • Protein damage

Solution: Understand, Test Regularly, and Treat Preventatively

For the treatment of oxidative stress, we first treat the root cause of the pathology for an individual. If it is a nutritional deficiency, leaky gut, an underlying infection, heavy metal toxicity, Lyme disease, or another diagnosis, that should be a primary course of treatment.

The Methylation processes in the body are also tied to the health of cell mitochondria and oxidative stress. This complicated process is crucial for detoxification in the body…in the liver and the brain, in DNA and enzymes. Fortunately, there are broad strokes that can improve methylation throughout the body. Lowering the burden of oxidative stress helps with methylation.

In general, for oxidative stress, some key treatments might be:

  • Antioxidants, especially Glutathione. The major intracellular antioxidant in our bodies is produced within our own bodies. Resveratrol, associated with longevity, increases our own production of glutathione, that is it turns on our own antioxidant production center. Every cell needs glutathione. High levels of glutathione help the body/brain detoxify, lower our risk for cancer, lessen damage to DNA, and diminish the risk of respiratory conditions.
  • CoQ10
  • Sulforaphane (from Broccoli)
  • Curcumin + black pepper
  • ALA (alpha-lipoic acid)